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Problemas dermatológicos dosis de, al menos, 3 mg/día. Existe una evidencia cientí- fica considerable que respalda los beneficios de la suple- mentación con AST (en el rango de 3-6 mg/día) para la salud de la piel. Al ser una molécula soluble en lípidos, debe ingerirse con o inmediatamente después de las comidas, para asegurar una absorción óptima. Parece bien tolerada hasta dosis de 12 mg/día, y no se han infor- mado eventos adversos graves. l Bibliografía Bowe WP, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis: back to the future? Gut Pathogens. 2011; 3(1): 1. Bustamante M, Oomah BD, Oliveira WP, Burgos-Díaz C, Rubilar M, Shene C. Probiotics and prebiotics potential for the care of skin, female urogenital tract, and respiratory tract. Folia Microbiol (Praha). 2020; 65(2): 245-264. De Miranda RB, Weimer P, Rossi RC. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol. 2021 \\\\\\\[DOI: 10.1111/ijd.15518\\\\\\\] \\\\\\\[Online ahead of print\\\\\\\]. Dini I, Laneri S. Nutricosmetics: a brief overview. Phyther Res. 2019; 33: 3.054-3.063. Huang BL, Cahndra S, Shih BQ. Skin manifestations of inflammatory bowel disease. Front Physiol. 2012; 3: 13. Marzano AV, Borghi A, Stadnicki A, Crosti C, Cugno M. Cutaneous manifestations in patients with inflammatory bowel diseases: pathophysiology, clinical features and therapy. Inflamm Bowel Dis. 2014; 20: 213-227. McDaniel JC, Massey K, Nicolaou A. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. Wound Repair Regen. 2011; 19: 189-200. Neukam K, De Spirt S, Stahl W, Bejot M, Maurette JM, Tronnier H, et al. Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and condition. Skin Pharmacol Physiol. 2011; 24(2): 67-74. Ng QX, De Deyn MLZQ, Loke W, Foo NX, Chan HW, Yeo WS. Effects of astaxanthin supplementation on skin health: a systematic review of clinical studies. J Diet Suppl. 2021; 18(2): 169-182. Pappas A, Liakou A, Zouboulis CC. Nutrition and skin. Rev Endocr Metab Disord. 2016; 17(3): 443-448. Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014; 27: 113-119. Ribeiro WR, Queiroz AG, Mendes E, Casaro MB, Nascimento CM, Coelho LSSF, et al. Preventive oral supplementation with Bifidobacterium longum 51A alleviates oxazolone-induced allergic contact dermatitis-like skin inflammation in mice. Benef Microbes. 2021; 12(2): 199-209. Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2011; 3: a004978. Shamloul N, Hashim PW, Nia JJ, Farberg AS, Goldenberg G. The role of vitamins and supplements on skin appearance. Cutis. 2019; 104(4): 220-224. Shapiro SS, Saliou C. Role of vitamins in skin care. Nutrition. 2001; 17(10): 839-844. Solà Marsiñach M, Cuenca AP. The impact of sea buckthorn oil fatty acids on human health. Lipids Health Dis. 2019; 18(1): 145. Teleszko M, Wojdyło A, Rudzińska M, Oszmiański J, Golis T. Analysis of lipophilic and hydrophilic bioactive compounds content in sea buckthorn (Hippophaë rhamnoides L.) berries. J Agric Food Chem. 2015; 63(16): 4.120-4.129. Varani J, Dame MK, Rittie L, Fligiel SEG, Kang S, Fisher GJ, et al. Decreased collagen production in chronologically aged skin: roles of age- dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006; 168(6): 1.861-1.868. Yang M, Zhou M, Song L. A review of fatty acids influencing skin condition. J Cosmet Dermatol. 2020; 19(12): 3.199-3.204. Žmitek K, Žmitek J, Rogl Butina M, Pogačnik T. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: results of a randomised, placebo-controlled, double-blind study. Nutrients. 2020; 12(3): 618. A ¡Acceda a www.aulamayofarmacia.com para seguir el curso! 56 octubre 2022 – el farmacéutico n.o 614